Developmental pharmacology

Developmental pharmacology: overview.

Zinc phthalocyanine substituted with four hydroxyl groups attached to the macrocycle, either directly or via spacer chains of three or six carbon atoms, were tested for their photodynamic ability to inactivate Chinese hamster lung fibroblasts (line V-79) in vitro, and to induce regression of EMT-6 tumours grown subcutaneously in Balb/c mice. Their potential to inflict direct cell killing during...

Teratology and Developmental Pharmacology: Why Should Paediatricians Care?

It is important to adopt an evidence-based approach to support rational use of drugs during pregnancy and lactation, both to prevent malformations and to correct misperceptions about drug use during this critical period of life. To demonstrate the clinical effectiveness of a teratology information service and its relevance to the local child health practice, we use five clinical scenarios to il...

Anesthetic Pharmacology Preclinical Pharmacology

Daniel I. Sessler, MD† BACKGROUND: In previous studies, we showed that failure to respond to automated responsiveness monitor (ARM) precedes potentially serious sedationrelated adversities associated with loss of responsiveness, and that the ARM was not susceptible to false-positive responses. It remains unknown, however, whether loss and return of response to the ARM occur at similar sedation ...

Pharmacology.

A very able review of the present status of the pharmacology of cannabis, active substances and synthetic derivatives, has been given by S. Loewe. In conjunction with other recognized American investigators, Roger Adams, E. J. Wollner, et al., he has himself made important contributions to this subject. The large number of animals at his disposal, for example, 2600 experiments carried out on 15...

Pharmacology